TPCMOD 0018 2005 - 07 - 22 Vesa Oikonen NET and [ 18 F ] FDOPA PET : Literature review
نویسنده
چکیده
Somatostatin receptor scintigraphy (SNS) with In-labelled somatostatin receptor analog is a standard procedure for the detection and staging of neuroendocrine tumors (NETs, APUDomas). NETs can be small and situated almost throughout the body. This heterogeneous group of tumors take up amino acids, transform them into biogenic amines (dopamine and serotonin) by decarboxylation, and store the amines in vesicles; this is the so-called APUD (amino precursor uptake and decarboxylation) concept. L-Dihydroxyphenylalanine (L-DOPA) is a precursor of catecholamines (dopamine, noradrenalin and adrenalin). Its conversion to dopamine is catalysed by the aromatic amino acid decarboxylase (AADC).
منابع مشابه
PET studies of net blood-brain clearance of FDOPA to human brain: age-dependent decline of [18F]fluorodopamine storage capacity.
Conventional methods for the graphical analysis of 6-[(18)F]fluorodopa (FDOPA)/positron emission tomography (PET) recordings (K(in)(app)) may be prone to negative bias because of oversubtraction of the precursor pool in the region of interest, and because of diffusion of decarboxylated FDOPA metabolites from the brain. These effects may reduce the sensitivity of FDOPA/PET for the detection of a...
متن کامل18F-fluorodihydroxyphenylalanine PET/CT in patients with neuroendocrine tumors of unknown origin: relation to tumor origin and differentiation.
UNLABELLED This work was performed to evaluate the performance of (18)F-fluorodihydroxyphenylalanine ((18)F-FDOPA) PET/CT in detecting primary neuroendocrine tumors (NETs) occult on morphologic and functional imaging, in relation to tumor origin and differentiation. METHODS A retrospective study of NET patients who were investigated with (18)F-FDOPA PET/CT imaging in 2 academic endocrine tumo...
متن کاملTreatment response evaluation using 18F-FDOPA PET in patients with recurrent malignant glioma on bevacizumab therapy.
PURPOSE This study compares the value of 3,4-dihydroxy-6-[(18)F]-fluoro-l-phenylalanine ((18)F-FDOPA) positron emission tomography (PET) and MRI in assessing outcome during antiangiogenic treatment in patients with recurrent high-grade gliomas. EXPERIMENTAL DESIGN Thirty patients were prospectively studied with (18)F-FDOPA PET scans immediately before, and two and six weeks after start of bev...
متن کامل18F-FDOPA PET imaging of brain tumors: comparison study with 18F-FDG PET and evaluation of diagnostic accuracy.
UNLABELLED We evaluated the amino acid and glucose metabolism of brain tumors by using PET with 3,4-dihydroxy-6-(18)F-fluoro-l-phenylalanine ((18)F-FDOPA) and (18)F-FDG. METHODS Eighty-one patients undergoing evaluation for brain tumors were studied. Initially, 30 patients underwent PET with (18)F-FDOPA and (18)F-FDG within the same week. Tracer kinetics in normal brain and tumor tissues were...
متن کامل18F-FDOPA PET/MRI fusion in patients with primary/recurrent gliomas: initial experience.
BACKGROUND AND PURPOSE (18)F-FDOPA PET demonstrates higher sensitivity and specificity for gliomas than traditional [(18)F] FDG PET imaging. However, PET provides limited anatomic localization. The purpose of this study was to determine whether (18)F-FDOPA PET/MRI fusion can provide precise anatomic localization of abnormal tracer uptake and how this activity corresponds to MR signal abnormalit...
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